2. Academic Validation
  3. Antiviral C-25 epimers of 26-acetoxy steroids from the South China Sea gorgonian Echinogorgia rebekka

Antiviral C-25 epimers of 26-acetoxy steroids from the South China Sea gorgonian Echinogorgia rebekka

  • J Nat Prod. 2014 Jun 27;77(6):1488-93. doi: 10.1021/np500252q.
Fei Cao 1,  Chang-Lun Shao,  Min Chen,  Meng-Qi Zhang,  Kai-Xia Xu,  Hong Meng,  Chang-Yun Wang
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 24882250 DOI: 10.1021/np500252q
Abstract

Four new Steroids with an acetoxy linked at the end of the side chain, echrebsteroids A-D (1-4) were obtained from the South China Sea gorgonian Echinogorgia rebekka. The absolute configurations of 1-3 were determined using the modified Mosher's method on the hydrolysis products. The isolation of the pair of epimers (2 and 3) represents the first reported separation of C-25 epimers of 26-acetoxy Steroids. The (25R)-epimer (3) exhibited promising Antiviral activity against respiratory syncytial virus with an IC50 value of 0.19 μM and a comparatively higher therapeutic ratio (TC50/IC50 = 128).

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