Recent developments in biological activities of chalcones: a mini review

Eur J Med Chem. 2014 Oct 6:85:758-77. doi: 10.1016/j.ejmech.2014.08.033.

Parvesh Singh ¹, Amit Anand ², Vipan Kumar ³

Affiliations

1 School of Chemistry and Physics, University of KwaZulu Natal, P/Bag X54001, Westville, Durban 4000, South Africa.
2 Department of Chemistry, Khalsa College, Amritsar 143005, India.
3 Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: [email protected].

PMID: 25137491 DOI: 10.1016/j.ejmech.2014.08.033

Abstract

Chalcones represent key structural motif in the plethora of biologically active molecules including synthetic and natural products. Synthetic manipulations of Chalcones or their isolation from natural sources are being investigated worldwide for the development of more potent and efficient drugs for the treatment of several dreadful diseases such as Cancer, diabetes, HIV, tuberculosis, malaria etc. Over the past few years, a large volume of research papers and review articles highlighting the significance of chalcone derivatives has been compiled in the literature. The present review article focuses on the recent developments (2010-2014) on various pharmacological and medicinal aspects of Chalcones and their analogues.

Keywords

Anti-HIV; Anticancer agents; Antimalarials; Antimicrobials; Antiprotozal; Chalcones.

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