2. Academic Validation
  3. Role and regulation of RUNX2 in osteogenesis

Role and regulation of RUNX2 in osteogenesis

  • Eur Cell Mater. 2014 Oct 23:28:269-86. doi: 10.22203/ecm.v028a19.
M Bruderer 1,  R G Richards,  M Alini,  M J Stoddart
Affiliations

Affiliation

  • 1 AO Research Institute Davos, Clavadelerstrasse 8, CH-7270 Davos Platz, [email protected].
PMID: 25340806 DOI: 10.22203/ecm.v028a19
Abstract

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.

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