Anti-inflammatory secoiridoid glycosides from Gentianella azurea

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5260-4. doi: 10.1016/j.bmcl.2014.09.055.

Yu-jie Huang ¹, Hui Lu ¹, Xue-li Yu ¹, Wei-bing Song ¹, Shu-wei Zhang ¹, Lin-yin Fen ¹, Li-jiang Xuan ²

Affiliations

1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
2 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. Electronic address: [email protected].

PMID: 25442320 DOI: 10.1016/j.bmcl.2014.09.055

Abstract

A phytochemical investigation on crude extract of Gentianella azurea led to the isolation of ten new (1-10) and one known (11) secoiridoid glycosides. Their structures were unambiguously elucidated by analysis of 1D and 2D NMR. Compounds 2, 5 and 11 were found to inhibit nitric oxide (NO) production in RAW 264.7 macrophages with IC50 values of 52.78 ± 8.61, 0.69 ± 0.23 and 5.18 ± 1.33, respectively, while indomethacin, the positive control, showed an IC50 value of 1.25 ± 0.52 μM.

Keywords

Anti-inflammatory; Gentianella azurea (Gentianaceae); Nitric oxide; Secoiridoid glucosides.

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