2. Academic Validation
  3. Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders

Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders

  • J Med Chem. 2015 Jan 8;58(1):96-110. doi: 10.1021/jm5016044.
Divya Chaudhary 1,  Shaughnessy Robinson,  Donna L Romero
Affiliations

Affiliation

  • 1 Nimbus Discovery , 25 First Street, Suite 404, Cambridge, Massachusetts 02141, United States.
PMID: 25479567 DOI: 10.1021/jm5016044
Abstract

IRAK4, a serine/threonine kinase, plays a key role in both inflammation and oncology diseases. Herein, we summarize the compelling biology surrounding the IRAK4 signaling node in disease, review key structural features of IRAK4 including selectivity challenges, and describe efforts to discover clinically viable IRAK4 inhibitors. Finally, a view of knowledge gained and remaining challenges is provided.

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