2. Academic Validation
  3. Synthesis and antiproliferative activity of novel polynuclear heterocyclic compounds derived from 2,3-diaminophenazine

Synthesis and antiproliferative activity of novel polynuclear heterocyclic compounds derived from 2,3-diaminophenazine

  • Eur J Med Chem. 2015 Jan 27:90:568-76. doi: 10.1016/j.ejmech.2013.12.007.
Asma M Mahran 1,  Sherif Sh Ragab 2,  Ahmed I Hashem 3,  Mamdouh M Ali 4,  Afaf A Nada 2
Affiliations

Affiliations

  • 1 Photochemistry Department, National Research Center, Dokki, Giza, Egypt. Electronic address: [email protected].
  • 2 Photochemistry Department, National Research Center, Dokki, Giza, Egypt.
  • 3 Department of Chemistry, Faculty of Science, Ain Shams University, Egypt.
  • 4 Biochemistry Department, Division of Genetic Engineering and Biotechnology, National Research Centre, Dokki, Giza, Egypt.
PMID: 25497130 DOI: 10.1016/j.ejmech.2013.12.007
Abstract

2,3-Diaminophenazine 1 was used as a precursor for the preparation of some novel phenazine derivatives such as imidazo[4,5-b]phenazine-2-thione 2, its methylthio 3, ethyl 1-aryl-3H-[1,2,4]triazolo[2,3-a]imidazo[4,5-b]phenazines 8a-c, ethyl (2Z)-[3-aminophenazin-2-yl)amino](phenylhydrazono)ethanoate 9, pyrazino[2,3-b]phenazine derivatives 10, 12, 15-17, [1,4]diazepino[2,3-b]phenazine derivatives 13, 14, 2,3-dibenzoylaminophenazine 18, 1H-Imidazo[4,5-b]phenazine derivatives 20, 23a-c, 24, 25 and 4-[(E)-(3-amino phenazin-2-yl)diazenyl] derivatives 27-29. All compounds were tested as inhibitors of the proliferation of human lung carcinoma and colorectal Cancer cell lines through inhibition of Tyrosine Kinases. Most of compounds exert good activity against the two Cancer cell lines. Five compounds (1, 2, 3, 25 and 28) were found to possess the same activity as the standard drug Cisplatin.

Keywords

Antiproliferative; Azo; Diazepine; Imidazole; Phenazine; Pyrazine.

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