2. Academic Validation
  3. Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana

Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana

  • Nat Prod Res. 2015;29(17):1684-7. doi: 10.1080/14786419.2014.991321.
Joseph T Ndongo 1,  Mark E Issa,  Angelique N Messi,  Joséphine Ngo Mbing,  Muriel Cuendet,  Dieudonné E Pegnyemb,  Christian G Bochet
Affiliations

Affiliation

  • 1 a Department of Chemistry , Higher Teacher Training College, University of Yaoundé 1 , P.O. Box 47, Yaoundé , Cameroon.
PMID: 25553908 DOI: 10.1080/14786419.2014.991321
Abstract

Seven Flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.

Keywords

Ochna schweinfurthiana; Ochnaceae; cytotoxic activity; flavonoids.

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