2. Academic Validation
  3. The potential of minor ginsenosides isolated from the leaves of Panax ginseng as inhibitors of melanogenesis

The potential of minor ginsenosides isolated from the leaves of Panax ginseng as inhibitors of melanogenesis

  • Int J Mol Sci. 2015 Jan 13;16(1):1677-90. doi: 10.3390/ijms16011677.
Dae-Young Lee 1,  Byeong-Ju Cha 2,  Young-Seob Lee 3,  Geum-Soog Kim 4,  Hyung-Jun Noh 5,  Seung-Yu Kim 6,  Hee Cheol Kang 7,  Jin Hee Kim 8,  Nam-In Baek 9
Affiliations

Affiliations

  • 1 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea. [email protected].
  • 2 Graduate School of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-706, Korea. [email protected].
  • 3 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea. [email protected].
  • 4 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea. [email protected].
  • 5 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea. [email protected].
  • 6 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea. [email protected].
  • 7 Research & Development Center, GFC Co., Ltd., Suwon 443-813, Korea. [email protected].
  • 8 College of Herbal Bio-industry, Daegu Haany University, Gyeongsan 712-715, Korea. [email protected].
  • 9 Graduate School of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-706, Korea. [email protected].
PMID: 25590297 DOI: 10.3390/ijms16011677
Abstract

Three minor ginsenosides, namely, ginsenoside Rh6 (1), vina-ginsenoside R4 (2) and vina-ginsenoside R13 (3), were isolated from the leaves of hydroponic Panax ginseng. The chemical structures were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy (FAB-MS), 1D-nuclear magnetic resonance (NMR), 2D-NMR, and, infrared (IR) spectroscopy. The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM. Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or Cosmetic Research. These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.

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