2. Academic Validation
  3. Diterpene alkaloids with an aza-ent-kaurane skeleton from Isodon rubescens

Diterpene alkaloids with an aza-ent-kaurane skeleton from Isodon rubescens

  • J Nat Prod. 2015 Feb 27;78(2):196-201. doi: 10.1021/np5006136.
Xu Liu 1,  Jing Yang,  Wei-Guang Wang,  Yan Li,  Ji-Zhou Wu,  Jian-Xin Pu,  Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
PMID: 25590529 DOI: 10.1021/np5006136
Abstract

Two compounds belonging to a new group of diterpene Alkaloids, kaurines A and B (1 and 2), and an alkaloid bearing a succinimide moiety (3) were obtained from Isodon rubescens. Their structures and absolute configurations were determined by spectroscopy and quantum-chemical computational (13)C NMR and ECD data analysis. These Alkaloids differ from known diterpene Alkaloids and Diterpenoids and are presumably biosynthesized from ent-kaurane Diterpenoids.

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