2. Academic Validation
  3. Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease

Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease

  • Mol Cell Proteomics. 2015 Mar;14(3):456-70. doi: 10.1074/mcp.O114.046565.
Rommel A Mathias 1,  Amanda J Guise 2,  Ileana M Cristea 3
Affiliations

Affiliations

  • 1 From the ‡Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544; §Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, 3086, Australia.
  • 2 From the ‡Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544;
  • 3 From the ‡Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544; [email protected].
PMID: 25616866 DOI: 10.1074/mcp.O114.046565
Abstract

Class IIa histone deacetylases (HDACs4, -5, -7, and -9) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems. The regulatory capacity of this family of Enzymes stems from their ability to shuttle between nuclear and cytoplasmic compartments in response to signal-driven post-translational modification. Here, we review the current knowledge of modifications that control spatial and temporal histone deacetylase functions by regulating subcellular localization, transcriptional functions, and cell cycle-dependent activity, ultimately impacting on human disease. We discuss the contribution of these modifications to cardiac and vascular hypertrophy, myoblast differentiation, neuronal cell survival, and neurodegenerative disorders.

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