2. Academic Validation
  3. New cytotoxic sesquiterpenoids from Siegesbeckia glabrescens

New cytotoxic sesquiterpenoids from Siegesbeckia glabrescens

  • Molecules. 2015 Feb 10;20(2):2850-6. doi: 10.3390/molecules20022850.
Qian Wu 1,  Hua Li 2,  So Yoon Lee 3,  Hwa Jin Lee 4,  Jae-Ha Ryu 5
Affiliations

Affiliations

  • 1 Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
  • 2 Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
  • 3 Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
  • 4 Department of Natural Medicine Resources, Semyung University, Chungbuk 390-711, Korea. [email protected].
  • 5 Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. [email protected].
PMID: 25690283 DOI: 10.3390/molecules20022850
Abstract

Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known Sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human Cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target Cancer cells with IC50 values in the range of 0.9-33.3 μM.

Figures
Products