2. Academic Validation
  3. Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro

Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro

  • Arch Pharm Res. 2015 Nov;38(11):1963-9. doi: 10.1007/s12272-015-0599-2.
Ha-Yeong Kim 1,  Hye Mi Kim 2,  Byeol Ryu 1,  Jae-Seung Lee 1,  Jung-Hye Choi 1 2,  Dae Sik Jang 3 4
Affiliations

Affiliations

  • 1 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea.
  • 2 College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea.
  • 3 Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea. [email protected].
  • 4 College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea. [email protected].
PMID: 25855013 DOI: 10.1007/s12272-015-0599-2
Abstract

A new terthiophene, 3'-hydroxy-2,2':5',2″-terthiophene-3'-O-β-D-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-D-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2-6), seven triterpenoids (8-14), two coumestans (15 and 16), and four Flavonoids (17-20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1-20 were evaluated for their cytotoxicity against human ovarian Cancer cells (SKOV3) using MTT assays.

Keywords

Cytotoxicity; Eclipta prostrata; Ovarian cancer; Terthiophene; Triterpenoid.

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