Runx2: Structure, function, and phosphorylation in osteoblast differentiation

Int J Biol Macromol. 2015:78:202-8. doi: 10.1016/j.ijbiomac.2015.04.008.

S Vimalraj ¹, B Arumugam ¹, P J Miranda ¹, N Selvamurugan ²

Affiliations

1 Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India.
2 Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India. Electronic address: [email protected].

PMID: 25881954 DOI: 10.1016/j.ijbiomac.2015.04.008

Abstract

RUNX2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in RUNX2 interact with several proteins and regulate a number of cellular events via posttranslational modifications. Hence, in this review we summarized the structural integrity of RUNX2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis.

Keywords

Bone; Osteoblast; Phosphorylation; Runx2.

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