2. Academic Validation
  3. Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent

Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent

  • Bioorg Med Chem Lett. 2015 Aug 15;25(16):3338-41. doi: 10.1016/j.bmcl.2015.05.067.
Pori Buragohain 1,  Naresh Surineni 1,  Nabin C Barua 2,  Purnajyoti D Bhuyan 1,  Paran Boruah 1,  Jagat C Borah 3,  Surbala Laisharm 3,  Dinesh Singh Moirangthem 3
Affiliations

Affiliations

  • 1 CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
  • 2 CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India. Electronic address: [email protected].
  • 3 Institute of Bioresources and Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
PMID: 26099535 DOI: 10.1016/j.bmcl.2015.05.067
Abstract

A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An Antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela Cancer cell line. All these derivatives have shown moderate to good activity.

Keywords

Anticancer; Antifungal; Artemisinin; Fusarium oxysporum; Suzuki cross-coupling.

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