New geranylated flavanones from the fruits of Paulownia catalpifolia Gong Tong with their anti-proliferative activity on lung cancer cells A549

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3686-9. doi: 10.1016/j.bmcl.2015.06.035.

Tian-yang Gao ¹, Xing Jin ², Wen-zhao Tang ³, Xiao-jing Wang ⁴, Yun-xue Zhao ²

Affiliations

1 Key Laboratory for Rare Disease of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 260062, PR China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medicine Sciences, Jinan 250022, PR China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China.
2 Department of Pharmacology, School of Medicine, Shandong University, Jinan 250012, PR China.
3 Key Laboratory for Rare Disease of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 260062, PR China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medicine Sciences, Jinan 250022, PR China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China. Electronic address: [email protected].
4 Key Laboratory for Rare Disease of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 260062, PR China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medicine Sciences, Jinan 250022, PR China. Electronic address: [email protected].

PMID: 26115572 DOI: 10.1016/j.bmcl.2015.06.035

Abstract

Three new geranylated flavanones, named as paucatalinone A (1), B (2), and isopaucatalinone B (3), were isolated from the fruits of Paulownia catalpifolia Gong Tong (Scrophulariaceae). Their structures were well determined by means of IR, MS, 1D and 2D NMR, and CD techniques. Paucatalinone A (1) is the first sample as a dimeric geranylated flavanone derivative isolated from natural products. Paucatalinone A (1) displayed good antiproliferative effects on human lung Cancer cells A549 and resulted in a clear increase of the percentage of cells in G1 phase and a decrease in the percentage of cells in S and G2/M phases in comparison with control cells.

Keywords

Antiproliferative activity; Geranylated flavanones; Lung cancer cells A549; Paulownia catalpifolia Gong Tong.

Name
Email *

	Sorry, but the email address you supplied was invalid.