2. Academic Validation
  3. Down regulation of MiR-93 contributes to endometriosis through targeting MMP3 and VEGFA

Down regulation of MiR-93 contributes to endometriosis through targeting MMP3 and VEGFA

  • Am J Cancer Res. 2015 Apr 15;5(5):1706-17.
Xuan Lv 1,  Pei Chen 2,  Wei Liu 1
Affiliations

Affiliations

  • 1 Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200127, China.
  • 2 Liver Cancer Institute and Zhongshan Hospital, Fudan University Shanghai, China.
PMID: 26175939
Abstract

Objective: This study aimed to explore the role of miRNAs in pathogenesis of endometriosis.

Methodology: Endometrial samples from 57 females with endometriosis and 44 non-endometriotic controls were compared for the expression of a selected group of miRNAs. The regulatory function on downstream target was also explored.

Results: The expression of miR-93 and miR106a was significantly reduced in endometriotic samples compared to that in non-endometriotic samples. High levels of MMP3 and VEGFA were detected in more than 50% ectopic endometrium tissues. A negative association was found between the expression of miR-93 and the protein levels of MMP3 (Pearson correlation, r=-0.39, P=0.0025) or VEGFA (Pearson correlation, r=-0.37, P=0.0047) in samples from endometriosis patients. Mechanistically, miR-93 targeted MMP3 and VEGFA by directly binding to the 3'UTR of MMP3 and VEGFA mRNAs, and thereby inhibited the proliferation, migration and invasive capability of endometrial stromal cells (ESCs).

Conclusion: The finding of this study suggests that deregulation of miR-93 contribute to endometriosis by up-regulation of MMP3 and VEGFA and thus provide potential therapeutic targets for the treatment of endometriosis.

Keywords

Endometriosis; invasion; microRNA; migration; proliferation.

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