2. Academic Validation
  3. Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans

Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans

  • J Nat Prod. 2015 Sep 25;78(9):2149-54. doi: 10.1021/np5009027.
Yunbao Liu 1,  Yong Li 1,  Jing Qu 1,  Shuanggang Ma 1,  Caixia Zang 1,  Yutian Zhang 1,  Shishan Yu 1
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 26241103 DOI: 10.1021/np5009027
Abstract

A cultured endophytic fungus, Guignardia mangiferae, isolated from the toxic plant Gelsemium elegans yielded five new Sesquiterpenes (1-5), two new polyketones (6 and 7), and two known terpene polyketones (8 and 9). Their structures were elucidated using spectroscopic methods. On the basis of circular dichroism, the absolute configurations of the new compounds were determined. Compounds 1, 3, 4, and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC50 values of 15.2, 6.4, 4.2, and 4.5 μM, respectively (positive control curcumin, IC50 = 3.9 μM).

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