2. Academic Validation
  3. Lupane- and Friedelane-Type Triterpenoids from Celastrus stylosus

Lupane- and Friedelane-Type Triterpenoids from Celastrus stylosus

  • Chem Biodivers. 2015 Aug;12(8):1222-8. doi: 10.1002/cbdv.201400269.
You-Min Ying 1 2,  Cui-Yu Li 1,  Yan Chen 1,  Jia-Gui Xiang 1,  Ling Fang 2,  Jian-Biao Yao 2,  Fa-Song Wang 3,  Ru-Wei Wang 2,  Wei-Guang Shan 4,  Zha-Jun Zhan 5
Affiliations

Affiliations

  • 1 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
  • 2 Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
  • 3 Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province and College of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, P. R. China.
  • 4 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)). [email protected].
  • 5 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)). [email protected].
PMID: 26265574 DOI: 10.1002/cbdv.201400269
Abstract

Two new triterpenoids, 30-hydroxylup-20(29)-ene 3β-caffeate (1) and 24-nor-friedelan-6α,10-dihydroxy-1,2-dioxo-4,7-dien-29-oic acid (2), together with eight known compounds 3-10, were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human Cancer cell lines (PANC-1, A549, PC-3, HepG2, SGC-7901, and HCCLM3) were evaluated. Compounds 3, 4, and 10 exhibited comparable activities against PC-3 and HCCLM3 cell lines as the positive control taxol.

Keywords

Antiproliferative activities; Celastrus stylosus; Friedelanes; Lupanes; Triterpenoids.

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