Estrogen receptor alpha and beta in health and disease

Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):557-68. doi: 10.1016/j.beem.2015.04.008.

Min Jia ¹, Karin Dahlman-Wright ², Jan-Åke Gustafsson ³

Affiliations

1 Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S-141 83 Huddinge, Sweden. Electronic address: [email protected].
2 Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S-141 83 Huddinge, Sweden; SciLifeLab, Department of Biosciences and Nutrition, Karolinska Institutet, S-171 21 Solna, Sweden. Electronic address: [email protected].
3 Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S-141 83 Huddinge, Sweden; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, 3605 Cullen Blvd. Science and Engineering Research Center Bldg. 545, Houston, TX 77204-5056, United States. Electronic address: [email protected].

PMID: 26303083 DOI: 10.1016/j.beem.2015.04.008

Abstract

Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as Cancer, metabolic and Cardiovascular Disease, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update on ERα and ERβ in health and disease with focus on their role in Cancer and Metabolic Disease and in the context of recent years' success in providing genome wide data on ER function. Furthermore, potential clinical applications and challenges are also discussed.

Keywords

cancer; estrogen receptors; metabolic disease.

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