2. Academic Validation
  3. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

  • J Antibiot (Tokyo). 2016 Feb;69(2):121-3. doi: 10.1038/ja.2015.94.
Hideaki Kakeya 1 2,  Daisuke Kaida 3 4,  Hiromi Sekiya 1,  Koji Nagai 5,  Minoru Yoshida 3,  Hiroyuki Osada 1
Affiliations

Affiliations

  • 1 Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
  • 2 Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
  • 3 Chemical Genetics Laboratory, RIKEN, Saitama, Japan.
  • 4 Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.
  • 5 Fermentation Research Division, Astellas Research Technologies Co. Ltd., Ibaraki, Japan.
PMID: 26350783 DOI: 10.1038/ja.2015.94
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