Fulminant hepatic failure (FHF) due to acute hepatitis C

Pak J Med Sci. 2015 Jul-Aug;31(4):1009-11. doi: 10.12669/pjms.314.7618.

Bilal Bin Younis ¹, Rozina Arshad ², Saima Khurhsid ³, Junaid Masood ⁴, Farhan Nazir ⁵, Maham Tahira ⁶

Affiliations

1 Bilal Bin Younis, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.
2 Rozina Arshad, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.
3 Saima Khurhsid, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.
4 Junaid Masood, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.
5 Farhan Nazir, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.
6 Maham Tahira, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.

PMID: 26430449 DOI: 10.12669/pjms.314.7618

Abstract

Acute hepatitis C (HCV) Infection has been identified as an important cause of fulminant hepatic failure (FHF), characterized by rapid deterioration of liver function from massive hepatic necrosis leading to encephalopathy and multi-organ failure. We admitted a female patient at Shalamar Hospital with jaundice, fever, encephalopathy and coagulopathy of short duration with no history of any comorbidity. Her hepatitis viral screen revealed positive anti HCV. Her viral loads were also high. A diagnosis of FHF due to acute HCV Infection was made. Patient was treated conservatively and improved gradually. In summary, acute HCV can cause FHF and should be ruled out in patients with FHF of unknown cause in an endemic country for HCV like Pakistan.

Keywords

Fulminant hepatic failure; HCV; Hepatitis.

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