2. Academic Validation
  3. The role of the 14-3-3 protein family in health, disease, and drug development

The role of the 14-3-3 protein family in health, disease, and drug development

  • Drug Discov Today. 2016 Feb;21(2):278-87. doi: 10.1016/j.drudis.2015.09.012.
Yasaman Aghazadeh 1,  Vassilios Papadopoulos 2
Affiliations

Affiliations

  • 1 The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada; Department of Medicine, McGill University, Montreal, QC H3G 1A4, Canada.
  • 2 The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada; Department of Medicine, McGill University, Montreal, QC H3G 1A4, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: [email protected].
PMID: 26456530 DOI: 10.1016/j.drudis.2015.09.012
Abstract

14-3-3 proteins regulate intracellular signaling pathways, such as signal transduction, protein trafficking, cell cycle, and Apoptosis. In addition to the ubiquitous roles of 14-3-3 isoforms, unique tissue-specific functions are also described for each isoform. Owing to their role in regulating cell cycle, protein trafficking, and steroidogenesis, 14-3-3 proteins are prevalent in human diseases, such as Cancer, neurodegeneration, and reproductive disorders, and, therefore, serve as valuable drug targets. In this review, we summarize the role of 14-3-3 proteins in normal and disease states, with a focus on 14-3-3γ and ɛ. We also discuss drug compounds targeting 14-3-3 proteins and their potential therapeutic uses.

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