2. Academic Validation
  3. Carbazole-pyranocoumarin conjugate and two carbazole alkaloids from the stems of Clausena excavata

Carbazole-pyranocoumarin conjugate and two carbazole alkaloids from the stems of Clausena excavata

  • Nat Prod Res. 2016 Aug;30(15):1690-7. doi: 10.1080/14786419.2015.1135143.
Suda Chakthong 1 2 3,  Nitima Bindulem 1 2,  Sirorat Raknai 1,  Sariya Yodwaree 1,  Soonthorn Kaewsanee 1,  Akkharawit Kanjana-Opas 4
Affiliations

Affiliations

  • 1 a Faculty of Science, Department of Chemistry , Prince of Songkla University , Hat Yai, Songkhla , Thailand.
  • 2 b Faculty of Science, Center of Excellence for Innovation in Chemistry , Prince of Songkla University , Hat Yai, Songkhla , Thailand.
  • 3 c Natural Product Research Center of Excellence , Prince of Songkla University , Hat Yai, Songkhla , Thailand.
  • 4 d Faculty of Agro-Industry, Department of Industrial Biotechnology , Prince of Songkla University , Hat Yai, Songkhla , Thailand.
PMID: 26824689 DOI: 10.1080/14786419.2015.1135143
Abstract

A carbazole-pyranocoumarin conjugate, carbazomarin B (1), and two Carbazole Alkaloids, 6-methoxymukonidine (2) and 2-hydroxy-3-methoxycarbazole (3), together with 27 known compounds (4-30), were isolated from the stems of Clausena excavata. Their structures have been elucidated by spectroscopic analyses. Compound 2 showed moderate cytotoxicity to HuCCA-1, MOLT-3 and HepG2 Cancer cell lines with IC50 values of 15.09-28.50 μg/mL, but none to A549 cell line. Heptaphylline (6) and nordentatin (23) were found to show moderate cytotoxic activity against HepG2 cell line with IC50 values of 12.33 and 11.33, respectively, while clausine K (27) exhibited strong cytotoxicity with IC50 value of 1.05 μg/mL, better than a standard drug (etoposide, IC50 13.40 μg/mL).

Keywords

Clausena excavata; Rutaceae; carbazole alkaloids; cytotoxic activity.

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