2. Academic Validation
  3. The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni

The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni

  • J Nat Prod. 1989 Nov-Dec;52(6):1353-6. doi: 10.1021/np50066a032.
T M Zabriskie 1,  C M Ireland
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
PMID: 2693614 DOI: 10.1021/np50066a032
Abstract

Two cytotoxic pyrrolo[2,3-d]pyrimidine nucleosides, toyocamycin and 5-(methoxycarbonyl)tubercidin, have been isolated from the Fijian Sponge Jaspis johnstoni. The structures were solved primarily by 13C nmr and mass spectral methods and confirmed by comparison to reported values in the literature. Small amounts of the corresponding aglycones were also isolated.

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