2. Academic Validation
  3. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing

Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing

  • Trends Genet. 2016 Jun;32(6):320-321. doi: 10.1016/j.tig.2016.03.006.
Ian A Roundtree 1,  Chuan He 2
Affiliations

Affiliations

  • 1 Department of Biochemistry and Molecular Biology, Medical Scientist Training Program, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
  • 2 Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics and Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address: [email protected].
PMID: 27050931 DOI: 10.1016/j.tig.2016.03.006
Abstract

N(6)-Methyladenosine (m(6)A) is emerging as a chemical MARK that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.

Keywords

N(6)-methyladenosine; YTHDC1; mRNA splicing.

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