2. Academic Validation
  3. Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L

Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L

  • Bioorg Med Chem Lett. 2016 Jun 15;26(12):2788-2794. doi: 10.1016/j.bmcl.2016.04.066.
Manh Tuan Ha 1,  Manh Hung Tran 2,  Kim Jeong Ah 3,  Kyung-Jin Jo 4,  Jaewang Kim 4,  Wook Dong Kim 5,  Woo Jae Cheon 5,  Mi Hee Woo 2,  Sung Ho Ryu 4,  Byung Sun Min 6
Affiliations

Affiliations

  • 1 College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay District, Hanoi, Vietnam.
  • 2 College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
  • 3 College of Pharmacy, Kyungpook National University, Daegu 702-701, Republic of Korea.
  • 4 Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
  • 5 Gyeongsanbuk-do Forest & Environment Research Institute, Gyeongju 780-936, Republic of Korea.
  • 6 College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea. Electronic address: [email protected].
PMID: 27156775 DOI: 10.1016/j.bmcl.2016.04.066
Abstract

Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three Flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50=0.012μM), with IC50 values ranging from 0.09 to 0.92μM.

Keywords

2-Arylbenzofuran; Geranylated stilbene; Moraceae; Morus alba; Pancreatic lipase.

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