2. Academic Validation
  3. Toxic Effects of Bromothalonil and Flutolanil on Multiple Developmental Stages in Zebrafish

Toxic Effects of Bromothalonil and Flutolanil on Multiple Developmental Stages in Zebrafish

  • Bull Environ Contam Toxicol. 2016 Jul;97(1):91-7. doi: 10.1007/s00128-016-1833-4.
Yang Yang 1,  Suzhen Qi 1,  Jiayi Chen 1,  Yong Liu 1,  Miao Teng 1,  Chengju Wang 2
Affiliations

Affiliations

  • 1 College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China.
  • 2 College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China. [email protected].
PMID: 27209543 DOI: 10.1007/s00128-016-1833-4
Abstract

In this study, we applied various developmental stages of zebrafish to address the potential environmental risk and aquatic toxicity of bromothalonil and flutolanil. This results demonstrated that the acute toxicity of bromothalonil to the three phases of zebrafish were 4.34 (embryo) < 3.27 (12 h old larvae) < 2.52 mg/L (adult fish) and that of flutolanil were 5.47 (embryo) < 4.09 (72 h old larvae) < 3.91 (12 h old larvae) < 2.70 mg/L (adult). Sublethal effects induced by both bromothalonil and flutolanil on zebrafish embryos were noted, including growth inhibition, abnormal spontaneous movement, slower heart rate, complete hatching failure, and morphological deformities. In addition, both bromothalonil and flutolanil could cause notochord deformation and short body length of larvae. This study provides a foundation for future investigation into the mechanism of bromothalonil and flutolanil toxicity in zebrafish.

Keywords

Bromothalonil; Flutolanil; Morphological deformities; Toxicity; Zebrafish.

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