2. Academic Validation
  3. An alternative route to the arylvinyltriazole nucleosides

An alternative route to the arylvinyltriazole nucleosides

  • Bioorg Med Chem Lett. 2016 Jul 15;26(14):3223-3225. doi: 10.1016/j.bmcl.2016.05.072.
Mikhail V Chudinov 1,  Alexander N Prutkov 2,  Andrey V Matveev 2,  Lyubov E Grebenkina 2,  Irina D Konstantinova 3,  Yulia V Berezovskaya 4
Affiliations

Affiliations

  • 1 Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454, Russia. Electronic address: [email protected].
  • 2 Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454, Russia.
  • 3 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 GSP, Moscow B-437, Russia.
  • 4 Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow Region 141700, Russia.
PMID: 27262598 DOI: 10.1016/j.bmcl.2016.05.072
Abstract

A new pathway to synthesis of arylvinyl ribavirin analogues is developed which makes it possible to obtain not only trans- but also cis-isomers at vinyl bond. By this route eight ribavirin 5-arylvinyl analogues are synthesized and their Antiviral activity is evaluated.

Keywords

HCV; Nucleoside analogues; Triazole nucleosides.

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