2. Academic Validation
  3. Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion

Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion

  • J Neurol Sci. 2016 Jul 15;366:91-93. doi: 10.1016/j.jns.2016.04.050.
Yuji Fujita 1,  Jun-Ichi Takanashi 2,  Haruka Takei 3,  Setsuo Ota 3,  Katsunori Fujii 4,  Hiroshi Sakuma 5,  Masaharu Hayashi 5
Affiliations

Affiliations

  • 1 Department of Pediatrics, Teikyo University Chiba Medical Center, Ichihara, Japan. Electronic address: [email protected].
  • 2 Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
  • 3 Department of Pediatrics, Teikyo University Chiba Medical Center, Ichihara, Japan.
  • 4 Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
  • 5 Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
PMID: 27288783 DOI: 10.1016/j.jns.2016.04.050
Abstract

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype of infectious pediatric encephalopathy in Japan. The exact pathogenesis of and the best therapeutic strategy for AESD are uncertain. We firstly performed a brain biopsy in a 2-year-old boy with AESD associated with RS viral Infection, which revealed activated ameoboid microglia accumulation around degenerated neuron, and astrogliosis in the affected cortex. Glutamate released from activated microglia may play an important role in the pathogenesis of AESD, which is compatible with the previous report of magnetic resonance spectroscopy showing elevated glutamate.

Keywords

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD); Encephalopathy; Glutamate; Microglia.

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