2. Academic Validation
  3. Bioactive Coumarins from the Stems of Clausena emarginata

Bioactive Coumarins from the Stems of Clausena emarginata

  • Chem Biodivers. 2016 Sep;13(9):1178-1185. doi: 10.1002/cbdv.201500519.
Guo-Qing Ouyang 1,  Chuang-Jun Li 1,  Jing-Zhi Yang 1,  Li Li 1,  Xiu-Yun Song 1,  Yi-Na Jiang 1,  Nai-Hong Chen 1,  Jie Ma 2,  Dong-Ming Zhang 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. [email protected].
  • 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. [email protected].
PMID: 27450780 DOI: 10.1002/cbdv.201500519
Abstract

Five new Coumarins, clauemarmarins I - M (1 - 4), together with 10 known analogs (5 - 14), were isolated from the stems of Clausena emarginata. Compounds 8 - 13 were obtained from this plant for the first time. Their structures were established and elucidated by comprehensive analysis of spectroscopic data. The absolute configurations of 1 - 4 were further determined by their electronic circular dichroism spectroscopy. Compounds 5, 7, 12, and 14 exhibited inhibitory effects on LPS-induced NO production. Compounds 5 - 7 showed selective neuroprotective effects in Aβ25 - 35 model at 10 μm.

Keywords

Clauemarmarins; Clausena emarginata; Inhibitory effects; Neuroprotective effects; Stems.

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