2. Academic Validation
  3. G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma

G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma

  • Tumour Biol. 2016 Oct;37(10):13333-13343. doi: 10.1007/s13277-016-5220-x.
Xiao-Dong Huang 1,  Feng-Jun Xiao 2,  Shao-Xia Wang 2,  Rong-Hua Yin 2,  Can-Rong Lu 1,  Qing-Fang Li 1,  Na Liu 1,  Ying Zhang 1,  Li-Sheng Wang 3,  Pei-Yu Li 4
Affiliations

Affiliations

  • 1 Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
  • 2 Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China.
  • 3 Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China. [email protected].
  • 4 Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. [email protected].
PMID: 27460081 DOI: 10.1007/s13277-016-5220-x
Abstract

Liposarcoma(LPS) is the most common type of soft tissue sarcoma accounting for 20 % of all adult sarcomas. However, the molecular pathogenesis of this malignancy is still poorly understood. Here, we showed that GPS2 expression was downregulated in LPS and correlated with the prognosis of this disease. In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without significant influence of cell death. Conclusively, our results suggest that GPS2 may act as a tumor suppressor in LPS and serve as a potential prognosis marker for this disease.

Keywords

DDLPS; GPS2; Liposarcoma; WDLPS.

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