Therapeutic potential of coumarins as antiviral agents

Eur J Med Chem. 2016 Nov 10:123:236-255. doi: 10.1016/j.ejmech.2016.07.056.

Mohd Zaheen Hassan ¹, Hasnah Osman ², Mohamed Ashraf Ali ³, Mohamed Jawed Ahsan ⁴

Affiliations

1 School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia; Department of Pharmaceutical Chemistry, Alwar Pharmacy College, M.I.A., Alwar, Rajasthan 301030, India. Electronic address: [email protected].
2 School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia. Electronic address: [email protected].
3 Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia.
4 Maharishi Arvind College of Pharmacy, Ambabari, Jaipur 302 039, India.

PMID: 27484512 DOI: 10.1016/j.ejmech.2016.07.056

Abstract

Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic Antiviral agents. A lot of structurally diverse Coumarins analogues were found to display remarkable array of affinity with the different molecular targets for Antiviral agents and slight modifications around the central motif result in pronounced changes in its Antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure-activity relationship studies of the coumarin analogues as Antiviral agents focusing mainly on lead optimization and its development into clinical candidates.

Keywords

Anti-HCV; Anti-HIV; Anti-herpes; Anti-influenza; Antiviral; Coumarin.

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