2. Academic Validation
  3. Synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones as potential antileukemic agents

Synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones as potential antileukemic agents

  • J Med Chem. 1989 Aug;32(8):1724-8. doi: 10.1021/jm00128a009.
B Stefanska 1,  M Dzieduszycka,  S Martelli,  E Borowski
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
PMID: 2754697 DOI: 10.1021/jm00128a009
Abstract

The synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones bearing one "mitoxantrone side arm" and another (aminoalkyl)amino moiety has been described. These unsymmetrical anthracene-9,10-diones exhibit cytotoxic activity against L1210 leukemia cells and antitumor activity against P388 leukemia in mice.

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