2. Academic Validation
  3. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis

Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis

  • Fitoterapia. 2016 Oct;114:92-97. doi: 10.1016/j.fitote.2016.08.012.
Ui Joung Youn 1,  Eun-Jung Park 2,  Tamara P Kondratyuk 3,  Tawanun Sripisut 3,  Surat Laphookhieo 4,  John M Pezzuto 2,  Leng Chee Chang 5
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States; Division of Life Sciences, Korea Polar Research Institute, KIOST, Incheon 21990, Republic of Korea.
  • 2 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States; Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, United States.
  • 3 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States.
  • 4 Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
  • 5 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States. Electronic address: [email protected].
PMID: 27575322 DOI: 10.1016/j.fitote.2016.08.012
Abstract

Bioassay-guided fractionation of the dichloromethane extract from the apical bud of Gardenia sootepenesis Hutch. (Rubiaceae) led to the isolation of four new cycloartane Triterpenes, sootepins F-I (1-4), along with four known derivatives (5-8). The structures of the new compounds were determined by 1D and 2D NMR experiments and by comparison of the physicochemical data with published values. The isolates were evaluated for Cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor-alpha (TNF-α)-induced nuclear factor kappa (NF-κB) activity. Compounds 6-8 inhibited TNF-α-induced NF-κB activity with half maximal inhibitory concentration (IC50) values of 8.3, 5.6, and 6.0μM, respectively; compounds 7 and 8 showed significant NO-inhibitory activity with IC50 values of 3.2 and 2.0μM, respectively.

Keywords

Anti-inflammatory activity; Coronalolide (Pubchem CID: 6479499); Coronalolide methyl ester (Pubchem CID: 5468948); Coronalonic acid (Pubchem CID: 10648063); Cycloartane triterpenes; Gardenia sootepenesis; Rubiaceae; Sootepin D (Pubchem CID: 44179869).

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