2. Academic Validation
  3. Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa

Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa

  • J Nat Prod. 2016 Sep 23;79(9):2376-83. doi: 10.1021/acs.jnatprod.6b00566.
Hyun Woo Kim 1,  Junha Park 1,  Kyo Bin Kang 1,  Tae Bum Kim 1,  Won Keun Oh 1,  Jinwoong Kim 1,  Sang Hyun Sung 1
Affiliations

Affiliation

  • 1 College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
PMID: 27588326 DOI: 10.1021/acs.jnatprod.6b00566
Abstract

Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells.

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