2. Academic Validation
  3. Molecular Markers in Bone and Soft-Tissue Tumors

Molecular Markers in Bone and Soft-Tissue Tumors

  • JBJS Rev. 2016 Aug 30;4(8):e5. doi: 10.2106/JBJS.RVW.15.00092.
Rosanna Wustrack 1,  Kumarasen Cooper 2,  Kristy Weber 2
Affiliations

Affiliations

  • 1 University of California, San Francisco, San Francisco, California.
  • 2 Departments of Pathology (K.C.) and Orthopaedic Surgery (K.W.), University of Pennsylvania, Philadelphia, Pennsylvania.
PMID: 27603273 DOI: 10.2106/JBJS.RVW.15.00092
Abstract

Many sarcomas such as osteosarcoma have complex molecular compositions and behaviors that make standardized treatment difficult for patients with these tumors. Chromosomal translocations are noted in specific bone and soft-tissue sarcomas, and there are molecular tests (polymerase chain reaction [PCR] and fluorescence in situ hybridization [FISH]) used for accurate diagnosis. The translocations noted in sarcomas may allow future therapeutic targeting.

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