2. Academic Validation
  3. Insights into the post-transcriptional regulation of the mitochondrial electron transport chain

Insights into the post-transcriptional regulation of the mitochondrial electron transport chain

  • Biochem Soc Trans. 2016 Oct 15;44(5):1491-1498. doi: 10.1042/BST20160100.
Tamara M Sirey 1 2,  Chris P Ponting 1
Affiliations

Affiliations

  • 1 Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, University of Edinburgh, Edinburgh, U.K.
  • 2 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K.
PMID: 27911731 DOI: 10.1042/BST20160100
Abstract

The regulation of the mitochondrial electron transport chain is central to the control of cellular homeostasis. There are significant gaps in our understanding of how the expression of the mitochondrial and nuclear genome-encoded components of the electron transport chain are co-ordinated, and how the assembly of the protein complexes that constitute the electron transport chain are regulated. Furthermore, the role post-transcriptional gene regulation may play in modulating these processes needs to be clarified. This review summarizes the current knowledge regarding the post-transcriptional gene regulation of the electron transport chain and highlights how noncoding RNAs may contribute significantly both to complex electron transport chain regulatory networks and to mitochondrial dysfunction.

Keywords

RNA-binding proteins; eukaryotic gene expression; metabolic regulation; microRNA; mitochondrial respiration.

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