2. Academic Validation
  3. Key Structural Elements for Cellular Uptake of Acinetobactin, a Major Siderophore of Acinetobacter baumannii

Key Structural Elements for Cellular Uptake of Acinetobactin, a Major Siderophore of Acinetobacter baumannii

  • Org Lett. 2017 Feb 3;19(3):500-503. doi: 10.1021/acs.orglett.6b03671.
Woon Young Song 1,  Dawa Jeong 1,  Jimin Kim 1,  Min Wook Lee 1,  Man Hwan Oh 2,  Hak Joong Kim 1
Affiliations

Affiliations

  • 1 Department of Chemistry, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
  • 2 Department of Nanobiomedical Science, Dankook University , Cheonan 31116, Republic of Korea.
PMID: 28102683 DOI: 10.1021/acs.orglett.6b03671
Abstract

Acinetobactin is a major siderophore utilized by the human pathogen Acinetobacter baumannii. The rapid acquisition of drug resistance by A. baumannii has garnered concern globally. Herein, acinetobactin and systematically generated analogues were prepared and characterized; the binding and cellular delivery of Fe(III) by the analogues were evaluated. This investigation not only led to the clarification of the physiologically relevant acinetobactin structure but also revealed several key structural elements for its functionality as a siderophore.

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