2. Academic Validation
  3. Isolation, characterization and antimicrobial activities of polyacetylene glycosides from Coreopsis tinctoria Nutt

Isolation, characterization and antimicrobial activities of polyacetylene glycosides from Coreopsis tinctoria Nutt

  • Phytochemistry. 2017 Apr:136:65-69. doi: 10.1016/j.phytochem.2016.12.023.
Jia Guo 1,  Ao Wang 1,  Ke Yang 1,  Hao Ding 2,  Yimin Hu 1,  Yumeng Yang 1,  Siqi Huang 1,  Jingguo Xu 1,  Tianxing Liu 1,  Haiyan Yang 3,  Zhihong Xin 4
Affiliations

Affiliations

  • 1 Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
  • 2 Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China; College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi, People's Republic of China.
  • 3 College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi, People's Republic of China.
  • 4 Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China. Electronic address: [email protected].
PMID: 28104231 DOI: 10.1016/j.phytochem.2016.12.023
Abstract

Polyacetylene glycosides, (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-β-D-glucopyranoside (trivially named coreoside E) and (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-β-L-arabinopyranosyl-(1 → 2)-β-D-glucopyranoside (trivially named coreoside F), were isolated from buds of Coreopsis tinctoria Nutt., together with one known compound, coreoside B. Their chemical structures were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivities. Coreoside E exhibited high levels of antimicrobial activity against Staphylococcus aureus and Bacillus anthracis with minimum inhibitory concentrations of 27 ± 0.27 and 18 ± 0.40 μM, respectively, whereas coreoside F and coreoside B showed weak antimicrobial activity against S. aureus and B. anthracis.

Keywords

Antimicrobial activity; Asteraceae; Coreopsis tinctoria Nutt.; Coreoside B; Coreoside E; Coreoside F; Polyacetylene glycosides.

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