2. Academic Validation
  3. Flavonoids from Erythrina schliebenii

Flavonoids from Erythrina schliebenii

  • J Nat Prod. 2017 Feb 24;80(2):377-383. doi: 10.1021/acs.jnatprod.6b00839.
Stephen S Nyandoro 1 2,  Joan J E Munissi 1 2,  Msim Kombo 1,  Clarence A Mgina 1,  Fangfang Pan 3,  Amra Gruhonjic 4,  Paul Fitzpatrick 4,  Yu Lu 5,  Bin Wang 5,  Kari Rissanen 3,  Máté Erdélyi 2 6
Affiliations

Affiliations

  • 1 Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam , P.O. Box 35061, Dar es Salaam, Tanzania.
  • 2 Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg SE-412 96, Sweden.
  • 3 Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box. 35, FI-40014 University of Jyvaskyla, Finland.
  • 4 Sahlgrenska Cancer Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
  • 5 Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute , Beijing 101149, People's Republic of China.
  • 6 Swedish NMR Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
PMID: 28112509 DOI: 10.1021/acs.jnatprod.6b00839
Abstract

Prenylated and O-methylflavonoids including one new pterocarpan (1), three new Isoflavones (2-4), and nineteen known natural products (5-23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32-64 μg mL-1 and 36.9-101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast Cancer cell line MDA-MB-231 indicated EC50 values of 13.0-290.6 μM (pure compounds) and 38.3 to >100 μg mL-1 (crude extracts).

Figures