2. Academic Validation
  3. C21orf57 is a human homologue of bacterial YbeY proteins

C21orf57 is a human homologue of bacterial YbeY proteins

  • Biochem Biophys Res Commun. 2017 Mar 11;484(3):612-617. doi: 10.1016/j.bbrc.2017.01.149.
Anubrata Ghosal 1,  Caroline Köhrer 1,  Vignesh M P Babu 1,  Kinrin Yamanaka 1,  Bryan W Davies 2,  Asha I Jacob 1,  Daniel J Ferullo 1,  Charley C Gruber 1,  Maarten Vercruysse 1,  Graham C Walker 3
Affiliations

Affiliations

  • 1 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • 2 Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
  • 3 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: [email protected].
PMID: 28153719 DOI: 10.1016/j.bbrc.2017.01.149
Abstract

The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its Bacterial and chloroplast counterparts, the HuYbeY protein is an RNase and that it retains sufficient function in common with Bacterial YbeY proteins to partially suppress numerous aspects of the complex phenotype of an Escherichia coli ΔybeY mutant. Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, results in a severe growth phenotype. This observation suggests that the function of HuYbeY in human cells is likely regulated through specific interactions with partner proteins similarly to the way YbeY is regulated in bacteria.

Keywords

C21orf57; RNase; YBEY; Yeast.

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