2. Academic Validation
  3. Englerins: A Comprehensive Review

Englerins: A Comprehensive Review

  • J Nat Prod. 2017 Mar 24;80(3):771-781. doi: 10.1021/acs.jnatprod.6b01167.
Zhenhua Wu 1,  Senzhi Zhao 1,  David M Fash 1,  Zhenwu Li 1,  William J Chain 1,  John A Beutler 2
Affiliations

Affiliations

  • 1 Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
  • 2 Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.
PMID: 28170253 DOI: 10.1021/acs.jnatprod.6b01167
Abstract

In the decade since the discovery of englerin A (1) and its potent activity in Cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney Cancer and Other conditions.

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