SGK1: The Dark Side of PI3K Signaling

Activation of the PI3K pathway is central to a variety of physiological and pathological processes. In these contexts, Akt is classically considered the de facto mediator of PI3K-dependent signaling. However, in recent years, accumulating data point to the existence of additional effectors of PI3K activity, parallel to and independent of Akt, that play critical and unique roles in mediating different developmental, homeostatic, and pathological processes. In this review, I summarize and discuss our current understanding of the function of the serine/threonine kinase SGK1 as a downstream effector of PI3K, and try to separate targets and pathways validated as uniquely SGK1-dependent from those shared with Akt.

AGC kinases; AKT; PDK1; PI3K; SGK1.