2. Academic Validation
  3. Benzofuran glycosides and coumarins from the bark of Streblus indicus (Bur.) Corner

Benzofuran glycosides and coumarins from the bark of Streblus indicus (Bur.) Corner

  • Phytochemistry. 2017 Jun;138:170-177. doi: 10.1016/j.phytochem.2017.01.011.
Ruijie He 1,  Yanjun Zhang 2,  Liangdeng Wu 2,  Hui Nie 2,  Yan Huang 3,  Buming Liu 3,  Shengping Deng 2,  Ruiyun Yang 2,  Shuai Huang 2,  Zhijie Nong 2,  Jun Li 4,  Haiyan Chen 5
Affiliations

Affiliations

  • 1 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin, 541006, PR China.
  • 2 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • 3 Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, PR China.
  • 4 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China. Electronic address: [email protected].
  • 5 Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, PR China. Electronic address: [email protected].
PMID: 28284566 DOI: 10.1016/j.phytochem.2017.01.011
Abstract

Two pairs of rare benzofuran glucoside epimers, indicuses A and B and indicuses C and D, three biogenetically related compounds indicuses E-G, and one coumarin indicus H, as well as 11 known compounds, were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of indicuses A-H were elucidated by NMR and MS data, as well as by CD. (S)-Marmesinin exhibited moderate antimicrobial activity in vitro against Bacillus subtilis and Saccharomyces cerevisiae. 7,8-Dihydroxy-3-(3-methyl-2-butenyl) coumarin, umbelliferone, and scopoletin displayed strong cytotoxic activity in vitro against human bladder carcinoma cell line EJ. The structure-activity relationships indicate that hydroxylation at C-7 in the cytotoxic compounds is crucial to their activities.

Keywords

Benzofuran glycoside; Coumarin; Cytotoxicity; Moraccae; Streblus indicus (Bur.) Corner; Streblus lour.

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