2. Academic Validation
  3. Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd

Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd

  • Molecules. 2017 Mar 28;22(4):540. doi: 10.3390/molecules22040540.
Sijian Wang 1,  Pingping Shi 2,  Lu Qu 3,  Jingya Ruan 4,  Shengcai Yang 5,  Haiyang Yu 6,  Yi Zhang 7,  Tao Wang 8
Affiliations

Affiliations

  • 1 Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
  • 2 Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
  • 3 Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
  • 4 Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
  • 5 Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
  • 6 Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
  • 7 Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
  • 8 Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. [email protected].
PMID: 28350346 DOI: 10.3390/molecules22040540
Abstract

Three new compounds, apetalumosides C₁ (1), D (2), and 1-thio--d-glucopyranosyl(1→1)-1-thio-α-d-glucopyranoside (3), together with twenty-two known ones (4-25) were obtained from the seeds of Lepidium apetalum Willd. Among the known isolates, 5-8, 10-13, 16-20, and 25 were obtained from the genus for the first time; 4, 14, 15, and 21-24 were isolated from the species for the first time. Meanwhile, the NMR data of 16 was first reported here. Their structures were determined by means of chemical and spectroscopic methods. On the other hand, their inhibitory effects on sodium oleate-induced triglyceride (TG) overloading in HepG2 cells were evaluated. As a result, two new compounds (1 and 2), together with known isolates 7-11, 13, 14, 16-18, 20, 21, and 25 possessed significant inhibitory effects in the cells.

Keywords

HepG2 cells; Lepidium apetalum; flavonoid glycosides; phenolic glycosides; triglyceride accumulation inhibitory effects.

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