2. Academic Validation
  3. Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity

Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity

  • Nat Prod Res. 2018 May;32(10):1145-1149. doi: 10.1080/14786419.2017.1320795.
Xin Liu 1,  Chengle Yin 1,  Yue Cao 1,  Jinge Zhou 2,  Tao Wu 2,  Zhihong Cheng 1
Affiliations

Affiliations

  • 1 a Department of Pharmacognosy , School of Pharmacy, Fudan University , Shanghai , China.
  • 2 b Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica , Shanghai University of Traditional Chinese Medicine , Shanghai , China.
PMID: 28441883 DOI: 10.1080/14786419.2017.1320795
Abstract

A new triterpenoid glycoside (1) and 15 known compounds (2-16) were isolated from the whole Plants of Gueldenstaedtia verna. The new compound (1) was identified as complogenin 22-O-β-d-glucopyranoside by extensive spectroscopic techniques including 1D (1H and 13C) and 2D NMR experiments (HSQC, HMBC and NOESY), HR-DART-MS and chemical methods. Most of the isolates were evaluated for their inhibitory activities on LPS-induced NO production in RAW 264.7 cells. The inhibitory effects of the active compounds, sulphuretin (8) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (13), on the production of pro-inflammatory mediators (including IL-6, IL1β and PGE2) were further estimated in vitro by ELISA in RAW 264.7 macrophages.

Keywords

Gueldenstaedtia verna; anti-inflammatory; inhibition of NO production; triterpenoid glycoside.

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