2. Academic Validation
  3. Two new kaurane-type diterpenoids from Wedelia chinensis (Osbeck.) Merr

Two new kaurane-type diterpenoids from Wedelia chinensis (Osbeck.) Merr

  • Nat Prod Res. 2017 Nov;31(21):2531-2536. doi: 10.1080/14786419.2017.1317775.
Cancan Cai 1 2,  Yu Zhang 1,  Dongqiong Yang 1 2,  Xiaojiang Hao 1,  Shunlin Li 1
Affiliations

Affiliations

  • 1 a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
  • 2 b University of Chinese Academy of Sciences , Beijing , China.
PMID: 28475376 DOI: 10.1080/14786419.2017.1317775
Abstract

Two new kaurane-type Diterpenoids, 3α-(angeloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (1) and 3α-(tigloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (2), along with 10 known compounds (3-12) were isolated from the whole plant of Wedelia chinensis (Osbeck.) Merr. Their structures were elucidated on the basis of extensive spectroscopic analyses (UV, IR, MS and NMR) and comparison with literature data. Compounds 3 and 4 showed moderate inhibitory activity against the Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 19.35 and 18.31 μg/mL, respectively.

Keywords

Wedelia chinensis; antibacterial activity; kaurane-type diterpenoids.

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