2. Academic Validation
  3. Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells

Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells

  • J Nat Med. 2017 Oct;71(4):606-616. doi: 10.1007/s11418-017-1082-9.
Koji Fujihara 1,  Kunio Takahashi 1,  Kiyotaka Koyama 1,  Kaoru Kinoshita 2
Affiliations

Affiliations

  • 1 Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo, 204-8588, Japan.
  • 2 Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo, 204-8588, Japan. [email protected].
PMID: 28497306 DOI: 10.1007/s11418-017-1082-9
Abstract

Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure. The dose-dependent activities of compounds 1 and 3 on melanin synthesis were investigated.

Keywords

B16; Cactus; Chichipegenin; Chichipenoside; Melanin; Oleanolic acid; Polaskia chichipe; Saponins.

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