Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Cell. 2017 Jun 1;169(6):985-999. doi: 10.1016/j.cell.2017.05.016.

Roel Nusse ¹, Hans Clevers ²

Affiliations

1 Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].
2 Hubrecht Institute, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

PMID: 28575679 DOI: 10.1016/j.cell.2017.05.016

Abstract

The Wnt signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to Cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

Keywords

Wnt; cancer; development; stem cells; therapy.

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