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  2. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice

Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice

  • Food Chem Toxicol. 2017 Sep;107(Pt A):138-149. doi: 10.1016/j.fct.2017.06.041.
Di Zhu 1 Xinglin Zhang 1 Yajie Niu 1 Zhijun Diao 1 Bo Ren 1 Xingyu Li 1 Zhigang Liu 1 Xuebo Liu 2
Affiliations

Affiliations

  • 1 Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
  • 2 Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. Electronic address: [email protected].
Abstract

Cichoric acid (CA), extracted from edible Plants and vegetables, is a potential natural nutraceutical, with antioxidant and hypoglycaemic biological functions. The objective of this study was to explore the potential underlying molecular mechanisms involved in normalizing diabetes-related changes in hyperglycaemia via pancreas Apoptosis and muscle injury induced by multiple low-dose STZ (MLD-STZ) injection in response to dietary supplementation with CA. To induce the MLD-STZ diabetic mice, the C57BL/6J mice were intraperitoneally injected with STZ (50 mg/kg body weight) for consecutive five days. CA (60 mg/kg/d) was supplemented in drinking water for 4 weeks. Compared with control, CA inhibited pancreas Apoptosis and adjusted islet function in diabetic mice, leading to an increase in Insulin generation and secretion. Moreover, CA regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses, which contributes to the improvement in athletic ability and diabetic myopathy. In general, CA is a natural food-derived compound with the potential application for regulating glucose homeostasis and improving diabetes and its complications.

Keywords

Cichoric acid; Glycogen synthesis; Hyperglycaemia; Inflammatory; MLD-STZ; Mitochondrial biogenesis.

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